Benefits of β-blockers in cancer treatment

Cancer is one of the leading causes death in world. Researchers keep attempting to develop therapy modalities decrease mortality and morbidity cancer patients by trying comprehend effect sympathetic nerves (through catecholamine adrenergic receptors) development. Catecholamine activation β-adrenergic receptors (β1-AR, β2-AR, β3-AR) may influence cytokine immunity system, initiate tumorigenesis, stimulate tumor-associated macrophage angiogenesis, tumor microenvironment, facilitate cell metastasis, increased progressivity cells. β-blockers inhibit on β-AR various types paths needed for cells develop. also apoptosis, pro-inflammatory mediators growth factors In addition, have benefits as supplementary therapy, increase chemoradiotherapy sensitivity, cardiotoxicity, improve cachexia. The are expected reduce survival rates patients. This review comprehensively assesses benefit b-blockers a part complete management